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dc.contributor.authorDe Groot, Renate-
dc.contributor.authorJolles, Jelle-
dc.contributor.authorVan Boxtel, Martin-
dc.contributor.authorStein, Areyh-
dc.contributor.authorBlauw, Gerard-Jan-
dc.contributor.authorVan de Bor, Margot-
dc.contributor.authorLumey, Bertie-
dc.descriptionDe Groot, R. H. M., Jolles, J., Van Boxtel, M. P. J., Stein, A. D., Blauw, G-J., Van de Bor, M., & Lumey, B. (2011). Prenatal famine exposure and cognition at age 59 years. International Journal of Epidemiology, 40, 327-337. DOI: 10.1093/ije/dyq261en_US
dc.description.abstractBackground Despite the perceived importance of early life nutrition for mental development, few studies have related gestational undernutrition to later-life cognitive functioning. We investigated the consequences of gestational exposure to the Dutch famine of 1944-1945 for cognitive functioning at age 59 y. Methods We recruited men and women who were 1) born in birth clinics in Amsterdam, Rotterdam, and Leiden, between January 1945 and March 1946, whose mothers experienced famine during or immediately preceding pregnancy (n= 354); 2) born in the same three institutions during 1943 and 1947, whose mothers did not experience famine during this pregnancy (n= 292); or 3) same sex siblings of those in the first two categories (n=311). We assessed cognitive performance at age 59 years by means of a comprehensive test battery. Results All cognitive functioning test scores were within normal ranges for this age group. There were no differences in cognitive performance at age 59 years between individuals exposed to gestational undernutrition and those without this exposure. For the General Cognitive Index, a summary measure across 6 functional domains (mean 100, standard deviation 15 points), famine exposure was associated with a decrease of 0.57 points (95% confidence interval -2.41, 1.28 points. Individuals exposed to famine in gestational weeks 1- 10 had a cognitive functioning index 4.36 (95% CI 8.04, 0.67) points lower than those without this exposure. Within-sibling-pair analyses gave consistent results. Conclusion We found no overall association between maternal exposure to acute famine in pregnancy and cognitive performance of the offspring at age 59 y, but cannot rule out an association specific to early pregnancy exposure.en_US
dc.subjectprenatal exposureen_US
dc.titlePrenatal famine exposure and cognition at age 59 yearsen_US
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